However, if you are looking for a nutritional solution to supplement your diet,  both a methylcobalamin or cyanocobalamin supplement will work for you.

On the balance of scientific evidence, the body may absorb cyanocobalamin better, but methylcobalamin is generally thought to have better retention rate because of its bioavailability. It also comes without any toxicity.

In addition, methylcobalamin comes with a valuable methyl group that may have additional health benefits.

In my opinion, the average person in good health won't go wrong with either. Getting more B12 can never be a bad thing.


Article References:

1. Kelly, N.D., G. (1997). The Coenzyme Forms of Vitamin B12: Toward an Understanding of their Therapeutic Potential. Retrieved from 
http://www.anaturalhealingcenter.com/documents/Thorne/articles/CoEnzymeB12.pdf

2. Donald, M. S. (2000). Metabolic vitamin B12 status on a mostly raw vegan diet with follow-up using tablets, nutritional yeast, or probiotic supplements. Annals of Nutrition and Metabolism, 44(5–6), 229–34.

3. K, T., & G, B. (2014). Treatment of vitamin B12 deficiency-methylcobalamine? Cyancobalamine? Hydroxocobalamin?-clearing the confusion. PubMed.Gov. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/25117994/.

4. Adams, J. F., Ross, S. K., Mervyn, L., Body, K., & King, P. (1971). Absorption of Cyanocobalamin, Coenzyme B12, Methylcobalamin, and Hydroxocobalamin at Different Dose Levels. Scandinavian Journal of Gastroenterology, Issue 3. Retrieved from https://www.tandfonline.com/doi/abs/10.3109/00365527109180702.

5. Paul, C., & Brady, D. M. (2017). Comparative Bioavailability and Utilization of Particular Forms of B12 Supplements With Potential to Mitigate B12-related Genetic Polymorphisms. PubMed. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/28223907.

6. Kim, H. I., Hyung, W. J., Song, K. J., Choy, S. H., Kim, C. B., & Noh, S. H. (2011). Oral vitamin B12 replacement: an effective treatment for vitamin B12 deficiency after total gastrectomy in gastric cancer patients. PubMed. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21556950.

7. Sharabi A, A., & Al, E. (2003). Replacement therapy for vitamin B12 deficiency: comparison between the sublingual and oral route. PubMed. Retrieved from https://www.ncbi.nlm.nih.gov/m/pubmed/14616423/.